Introduction Proteinuria causes lipid metabolism abnormalities. Material and methods The study included 60 patients (M:F 32:28), mean age 37.15? 9.85 years, with average glomerular filtration rate (GFR) 86.27? 19.81 mL/min, and average BMI 24.18?2.23 kg/m2. Regarding the level of glomerular proteinuria, patients were divided into four groups. The first group, with proteinuria levels less than 0.25 g/24h, included 15 patients (M:F 6:9) (control group), average age 34.66?4.82 years, with mean GFR 99.70? 12.94 mL/min, and mean BMI 23.28?3.50 kg/nr. The second group, with proteinuria between 0.26 and 1.0 g/24h, comprised 15 patients (M:F 9:6) with primary glomerulonephritis, mean age 37.87?9.65 years, with mean GFR 82.85?18.48 mL/min and mean BMI 23.83?1.57 kg/m2. The third group consisted of 15 patients (M:F 8:7) with primary glomerulonephritis, with proteinuria between 1.1 and 3.0 g/24h, average age 35.67? 13.29 years, mean GFR 82.85?I8.48 mL/min, and mean BMI 23.83?1.57 kg/m2. The fourth group, with proteinuria over 3.0 g/24h, included 15 patients (M:F 9:6) with primary' glomerulonephritis, mean age 40.40?9.75 years, with mean GFR 80.16?20.80 mL/min, and mean BMI 24.83?1.44 kg/m2. In order to assess the influence of proteinuria on apoprotein metabolism abnormalities we investigated apo A-l apo B, apo E and the apo A-I/apo B ratio. Results Results were statistically analyzed using Student's t-test, and the Mann-Whitney U test. Statistically, patients with proteinuria over 3.0 g/24h have significantly higher apoprotein B and apoprotein E values in the serum, as well as apo B/apo A-l compared to control subjects, and patients with proteinuria around 0.26-1.0 g/24h and proteinuria around 1.1-3.0 g/24h. Proteinuria leads to deterioration of apoprotein abnormalities. .