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Oxford University Press (OUP), The Journal of Infectious Diseases, 10(202), p. 1577-1584

DOI: 10.1086/656778

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Poor Clinical Outcome for Meningitis Caused byHaemophilus influenzaeSerotype A Strains Containing the IS1016‐bexADeletion

Journal article published in 2010 by Josilene B. T. Lima, Guilherme S. Ribeiro ORCID, Soraia M. Cordeiro, Edilane L. Gouveia, Kátia Salgado, Brian G. Spratt, Daniel Godoy, Mitermayer G. Reis ORCID, Albert I. Ko, Joice N. Reis
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Following introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, meningitis caused by serotypes other than Hib has gained importance. We conducted active hospital-based surveillance for meningitis over an 11-year period in Salvador, Brazil. H. influenzae isolates were serotyped and analyzed by PCR, pulsed-field gel electrophoresis and DNA sequencing to identify strains with a specific deletion (IS1016) in the bexA gene (IS1016-bexA). We identified 43 meningitis cases caused by non-type b H. influenzae: 28 (65%) were caused by type a (Hia), 9 (21%) by non-capsulated strains and 3 (7%) each by types e and f. Hia isolates clustered in two clonal groups; clonal group A strains (n=9) had the IS1016-bexA deletion. Among children