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American Medical Association, Archives of Neurology -Chigago-, 7(67)

DOI: 10.1001/archneurol.2010.128

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Mitochondrial respiratory chain dysfunction in muscle from patients with amyotrophic lateral sclerosis.

Journal article published in 2010 by Crugnola Veronica, Lucchini Valeria, Silani Vincenzo, Costanza Lamperti, Dario Ronchi, Lorenzo Peverelli, Alessandro Prelle, Monica Sciacco, Andreina Bordoni, Elisa Fassone, Francesco Fortunato, Stefania Corti ORCID, Nereo Bresolin, Salvatore Di Mauro, Gp Comi ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Amyotrophic lateral sclerosis (ALS) is a major cause of neurological disability and its pathogenesis remains elusive despite a multitude of studies. Although defects of the mitochondrial respiratory chain have been described in several ALS patients, their pathogenic significance is unclear.