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Frontiers Media, Frontiers in Neuroscience, (6)

DOI: 10.3389/fnins.2012.00197

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Symmetric Diffeomorphic Modeling of Longitudinal Structural MRI

Journal article published in 2013 by John Ashburner ORCID, Gerard R. Ridgway
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

This technology report describes the longitudinal registration approach that we intend to incorporate into SPM12. It essentially describes a group-wise intra-subject modeling framework, which combines diffeomorphic and rigid-body registration, incorporating a correction for the intensity inhomogeneity artifact usually seen in MRI data. Emphasis is placed on achieving internal consistency and accounting for many of the mathematical subtleties that most implementations overlook. The implementation was evaluated using examples from the OASIS Longitudinal MRI Data in Non-demented and Demented Older Adults.