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BioMed Central, Genome Biology, 2(8), p. R23

DOI: 10.1186/gb-2007-8-2-r23

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Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin-dependent kinase

Journal article published in 2007 by Alan M. Moses, Jean-Karim Hériché, Richard Durbin ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. Based on this, we introduce a new computational strategy to predict the targets of CDKs and use it to identify new biologically interesting candidates. Our data suggest that regulatory modules may exist in protein sequence as clusters of short sequence motifs.