Published in
Oxford University Press (OUP), The Journal of Infectious Diseases, 11(198), p. 1651-1655
DOI: 10.1086/593067
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Maternal Neutralizing Antibody and Transmission of Hepatitis C Virus to Infants
,
Ronald C. Hershow,
Sigal Yawetz,
Philip LaRussa,
Clemente Diaz,
Sheldon H. Landesman,
Mary E. Paul,
Jennifer S. Read,
Ming Lu,
David L. Thomas,
Dale M. Netski,
Stuart C. Ray
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Abstract
To determine if lower levels of hepatitis C virus (HCV)-specific neutralizing antibodies (nAb) are associated with an increased risk of mother-to-child transmission (MTCT) of HCV, anti-HCV nAb titers were assessed in 63 mothers co-infected with HCV and human immunodeficiency virus type 1 (HIV). Among the mothers, 16 transmitted HCV to their infant but no difference was detected between the ability of maternal plasma from transmitters and non-transmitters to neutralize heterologous HCV pseudoparticles (median nAb titer 1:125 vs. 1:100, P=0.23). In the setting of HIV/HCV co-infection, we found no evidence that anti-HCV nAbs are associated with prevention of MTCT of HCV.