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Public Library of Science, PLoS ONE, 5(7), p. e37198, 2012

DOI: 10.1371/journal.pone.0037198

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Spatial and Temporal Dynamics of Hepatitis B Virus D Genotype in Europe and the Mediterranean Basin

Journal article published in 2012 by Gianguglielmo Zehender, Erika Ebranati, Elena Gabanelli, Renata Shkjezi, Alessia Lai, Chiara Sorrentino, Alessandra Lo Presti, Mimoza Basho, Raffaele Bruno ORCID, Elisabetta Tanzi, Silvia Bino, Massimo Ciccozzi, Massimo Galli
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Hepatitis B virus genotype D can be found in many parts of the world and is the most prevalent strain in south-eastern Europe, the Mediterranean Basin, the Middle East, and the Indian sub-continent. The epidemiological history of the D genotype and its subgenotypes is still obscure because of the scarcity of appropriate studies. We retrieved from public databases a total of 312 gene P sequences of HBV genotype D isolated in various countries throughout the world, and reconstructed the spatio-temporal evolutionary dynamics of the HBV-D epidemic using a Bayesian framework.