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Oxford University Press, International Immunology, 9(26), p. 495-499, 2014

DOI: 10.1093/intimm/dxu066

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Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota

Journal article published in 2014 by Nicola Gagliani ORCID, Noah W. Palm, Marcel R. de Zoete ORCID, Richard A. Flavell ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Inflammasomes are large cytosolic protein complexes that detect infection and stress-associated signals and promote immediate inflammatory responses. In the intestine, activation of the inflammasome leads to an inflammatory response that is important for controlling enteric infections but can also result in pathological tissue damage. Recent studies have suggested that the inflammasome also regulates intestinal homeostasis through its effects on the intestinal microbiota. Notably, many conflicting studies have been published regarding the effect of inflammasome deficiencies on intestinal homeostasis. Here, we attempt to reconcile these contrasting data by highlighting the many ways that the inflammasome contributes to intestinal homeostasis and pathology and exploring the potential role of alterations in the microbiota in these conflicting studies.