Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Chemical Biology, 3(8), p. 232-234

DOI: 10.1038/nchembio.767

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Metabolomics Implicates Altered Sphingolipids in Chronic Pain of Neuropathic Origin

Journal article published in 2012 by Gary J. Patti, Oscar Yanes, Leah P. Shriver, Jean-Phillipe Courade, Ralf Tautenhahn, Marianne Manchester, Gary Siuzdak ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Neuropathic pain is a debilitating condition for which the development of effective treatments has been limited by an incomplete understanding of its chemical basis. We show by using untargeted metabolomics that sphingomyelin-ceramide metabolism is altered in the dorsal horn of rats with neuropathic pain and that the up-regulated, endogenous metabolite N,N-dimethylsphingosine induces mechanical hypersensitivity in vivo. These results demonstrate the utility of metabolomics to implicate unexplored biochemical pathways in disease.