Published in
American Society of Hematology, Blood, 15(127), p. 1896-1906, 2016
DOI: 10.1182/blood-2015-08-665679
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Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance
Journal article published in 2016 by
Bruno Paiva 
,
Luis A. Corchete,
Maria-Belen Vidriales ,
Noemi Puig,
Patricia Maiso,
Idoia Rodriguez,
Diego Alignani,
Leire Burgos,
Maria-Luz Sanchez,
Paloma Barcena,
Maria-Asuncion Echeveste,
Miguel T. Hernandez,
Ramón Garcia-Sanz,
Enrique M. Ocio,
Albert Oriol
and other authors.
,
Luis A. Corchete,
Maria-Belen Vidriales ,
Noemi Puig,
Patricia Maiso,
Idoia Rodriguez,
Diego Alignani,
Leire Burgos,
Maria-Luz Sanchez,
Paloma Barcena,
Maria-Asuncion Echeveste,
Miguel T. Hernandez,
Ramón Garcia-Sanz,
Enrique M. Ocio,
Albert Oriol
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points We report for the first time the biological features of MRD cells in MM and unravel that clonal selection is already present at the MRD stage. MRD cells show a singular phenotypic signature that may result from persisting clones with different genetic and gene expression profiles.