SAGE Publications, Journal of Histochemistry & Cytochemistry, 6(52), p. 833-836, 2004
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We investigated adenylyl cyclase activity of mouse spermatozoa by electron microscopic cytochemistry. Subcellular localization of enzyme activity was determined in the presence and absence of bicarbonate ions. Results confirm the existence in sperm of a bicarbonate-regulated adenylyl cyclase, which suggests microdomain signaling. (J Histochem Cytochem 52:833–836, 2004)