Published in

Taylor and Francis Group, Neurocase: The Neural Basis of Cognition, 6(20), p. 684-694, 2013

DOI: 10.1080/13554794.2013.826697

Links

Tools

Export citation

Search in Google Scholar

A cognitive chameleon: Lessons from a novelMAPTmutation case

Journal article published in 2013 by Yuying Liang, Elizabeth Gordon, Jonathan Rohrer, Laura Downey, Rohan de Silva, Hans Rolf Jäger ORCID, Jennifer Nicholas, Marc Modat, M. Jorge Cardoso, Colin Mahoney, Jason Warren, Martin Rossor, Nick Fox ORCID, Diana Caine
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Red circle
Preprint: archiving forbidden
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

We report a case of frontotemporal dementia caused by a novel MAPT mutation (Q351R) with a remarkably long amnestic presentation mimicking familial Alzheimer’s disease. Longitudinal clinical, neuropsychological and imaging data provide convergent evidence for predominantly bilateral anterior medial temporal lobe involvement consistent with previously established neuroanatomical signatures of MAPT mutations. This case supports the notion that the neural network affected in MAPT mutations is determined to a large extent by the underlying molecular pathology. We discuss the diagnostic significance of anomia in the context of atypical amnesia and the impact of impaired episodic and semantic memory systems on autobiographical memory.