Published in
American Association for the Advancement of Science, Science, 5975(328), p. 232-235, 2010
Elsevier, New Biotechnology, (27), p. S81, 2010
DOI: 10.1016/j.nbt.2010.01.227
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- [www.ncbi.nlm.nih.gov] | PDF
- [citeseerx.ist.psu.edu] | PDF
- [papers.gersteinlab.org] | PDF
- [infoscience.epfl.ch] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Variation in Transcription Factor Binding Among Humans
,
Joel Rozowsky,
Minyi Shi,
Alexander E. Urban,
Mi-Young Hong,
Konrad J. Karczewski ,
Wolfgang Huber ,
Sherman M. Weissman,
Mark B. Gerstein
and other authors.
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Abstract
Like Father, Like Mother, Like Child Transcriptional regulation is mediated by chromatin structure, which may affect the binding of transcription factors, but the extent of how individual-to-individual genetic variation affects such regulation is not well understood. Kasowski et al. (p. 232 , published online 18 March) investigated the binding of two transcription factors across the genomes of human individuals and one chimpanzee. Transcription factor binding was associated with genomic features such as nucleotide variation, insertions and deletions, and copy number variation. Thus, genomic sequence variation affects transcription factor binding and may explain expression difference among individuals. McDaniell et al. (p. 235 , published online 18 March) provide a genome-wide catalog of variation in chromatin and transcription factor binding in two parent-child trios of European and African ancestry. Up to 10% of active chromatin binding sites were specific to a set of individuals and were often inherited. Furthermore, variation in active chromatin sites showed heritable allele-specific correlation with variation in gene expression.