Dissemin is shutting down on January 1st, 2025

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Scientific Journals, Journal of Biology, 7(8), p. 61

DOI: 10.1186/jbiol170

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Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system

Journal article published in 2009 by Brigitta Stockinger ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The aryl hydrocarbon receptor is a ligand-activated transcriptional regulator that binds dioxin and other exogenous contaminants and is responsible for their toxic effects, including immunosuppression. New evidence suggests, however, that the aryl hydrocarbon receptor has a physiological role in the immune system, and the immunosuppressive effects of dioxin may reflect a more subtle disruption of the regulatory interactions between immune cells.