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Elsevier, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 8(1801), p. 799-805

DOI: 10.1016/j.bbalip.2010.04.004

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Phospholipase D in brain function and Alzheimer’s disease

Journal article published in 2010 by Tiago Gil Oliveira ORCID, Gilbert Di Paolo
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Alzheimer’s disease is the most common neurodegenerative disorder. Although lipids are major constituents of brain, their role in Alzheimer’s disease pathogenesis is poorly understood. Much attention has been given to cholesterol, but growing evidence suggests that other lipids, such as phospholipids, might play an important role in this disorder. In this review, we will summarize the evidence linking phospholipase D, a phosphatidic acid-synthesizing enzyme, to multiple aspects of normal brain function and to Alzheimer’s disease. The role of phospholipase D in signaling mechanisms downstream of beta-amyloid as well as in the trafficking and processing of amyloid precursor protein will be emphasized.