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Nature Research, Nature Genetics, 10(45), p. 1221-1225, 2013

DOI: 10.1038/ng.2733

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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

Journal article published in 2013 by Daniel Chubb, Niels Weinhold, Peter Broderick ORCID, Bowang Chen, David C. Johnson ORCID, Asta Försti, Jayaram Vijayakrishnan, Gabriele Migliorini, Sara E. Dobbins, Amy Holroyd, Dirk Hose, Brian A. Walker, Faith E. Davies, Walter A. Gregory, Graham H. Jackson and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10 -14), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10 -11), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10 -9) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10 -16). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.