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American Academy of Neurology (AAN), Neurology, 2(59), p. 272-274, 2002

DOI: 10.1212/wnl.59.2.272

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Total intracranial volume: Normative values and lack of association with Alzheimer's disease

Journal article published in 2002 by Sd D. Edland, Y. Xu, M. Plevak, P. O'Brien, Eg G. Tangalos, Rc C. Petersen, Cr R. Jack ORCID
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

A larger premorbid brain is hypothesized to provide neuronal reserve against AD. Using MRI data from ongoing studies of normal aging and AD, the authors tested this hypothesis. Mean total intracranial volume was 15.8 cm3 smaller for cases among women (n = 121 normal and 104 AD; p = 0.24) and 10.1 cm3 larger for cases among men (n = 63 normal and 62 AD; p = 0.59). These differences are small and nonsignificant, suggesting that head size per se is not a critical determinant of AD.