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BioMed Central, BMC Molecular Biology, 1(9), 2008

DOI: 10.1186/1471-2199-9-33

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The katG mRNA of Mycobacterium tuberculosis and Mycobacterium smegmatis is processed at its 5' end and is stabilized by both a polypurine sequence and translation initiation

Journal article published in 2008 by Claudia Sala ORCID, Francesca Forti, Francesca Magnoni, Daniela Ghisotti
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In Mycobacterium tuberculosis and in Mycobacterium smegmatis the furA-katG loci, encoding the FurA regulatory protein and the KatG catalase-peroxidase, are highly conserved. In M. tuberculosis furA-katG constitute a single operon, whereas in M. smegmatis a single mRNA covering both genes could not be found. In both species, specific 5' ends have been identified: the first one, located upstream of the furA gene, corresponds to transcription initiation from the furA promoter; the second one is the katG mRNA 5' end, located in the terminal part of furA.