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Elsevier, Antiviral Research, (101), p. 26-29, 2014

DOI: 10.1016/j.antiviral.2013.10.012

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Single-Dose Replication-Defective VSV-based Nipah Virus Vaccines Provide Protection from Lethal Challenge in Syrian Hamsters

Journal article published in 2013 by Michael K. Lo ORCID, Brian H. Bird, Anasuya Chattopadhyay, Clifton P. Drew, Brock E. Martin, Joann D. Coleman, John K. Rose, Stuart T. Nichol, Christina F. Spiropoulou
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This paper is available in a repository.

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Abstract

Nipah virus (NiV) continues to cause outbreaks of fatal human encephalitis due to spillover from its bat reservoir. We determined that a single dose of replication-defective vesicular stomatitis virus (VSV)-based vaccine vectors expressing either the NiV fusion (F) or attachment (G) glycoproteins protected hamsters from over 1000 times LD50 NiV challenge. This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans.