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Nature Research, Nature Genetics, 5(41), p. 521-523, 2009

DOI: 10.1038/ng.349

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

Journal article published in 2009 by Gijs van Haaften, Gillian L. Dalgliesh, Helen Davies, Lina Chen, Graham Bignell, Chris Greenman, Sarah Edkins, Claire Hardy, Sarah O'Meara, Jon Teague, Adam Butler, Jonathan Hinton, Calli Latimer, Jenny Andrews, Syd Barthorpe and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.