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Taylor and Francis Group, RNA Biology, 11(10), p. 1647-1652

DOI: 10.4161/rna.26706

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Aberrantly splicedHTT,a new player in Huntington’s disease pathogenesis

Journal article published in 2013 by Theresa A. Gipson, Andreas Neueder ORCID, Nancy S. Wexler, Gillian P. Bates, David Housman
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Huntington’s disease (HD) is an adult-onset neurodegenerative disorder caused by a mutated CAG repeat in the huntingtin gene that is translated into an expanded polyglutamine tract. The clinical manifestation of HD is a progressive physical, cognitive, and psychiatric deterioration that is eventually fatal.