SAGE Publications, Lupus, 2(5), p. 150-152, 1996
DOI: 10.1177/096120339600500211
Full text: Unavailable
Antiphospholipid antibodies were originally thought to bind negatively-charged (aniomic) phospholipids. Current evidence suggests that the target antigen is considerably more complex and includes β2-glycoprotein I, a phospholipid-binding plasma protein. Our under standing of the pathophysiology of the antiphospholipid syndrome has increased exponen tially with a number of studies into the interactions of antiphospholipid antibodies and β2-glycoprotein I.