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Elsevier, Vaccine, 48(30), p. 6777-6782, 2012

DOI: 10.1016/j.vaccine.2012.09.021

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Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity

Journal article published in 2012 by A. E. Gregory, E. D. Williamson, J. L. Prior, W. A. Butcher, I. J. Thompson, A. M. Shaw ORCID, R. W. Titball
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This paper is available in a repository.

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Abstract

The efficacy of 15 nm gold nanoparticles (AuNP) coated with Yersinia pestis F1-antigen, as an immunogen in mice, has been assessed. The nanoparticles were decorated with F1-antigen using N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide coupling chemistry. Mice given AuNP-F1 in alhydrogel generated the greatest IgG antibody response to F1-antigen when compared with mice given AuNP-F1 in PBS or given unconjugated F1-antigen in PBS or alhydrogel. Compared with unconjugated F1-antigen, the IgG2a response was enhanced in mice dosed with AuNP-F1 in PBS (p