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Ferrata Storti Foundation, Haematologica, 8(94), p. 1109-1123

DOI: 10.3324/haematol.2009.005983

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Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

Journal article published in 2009 by Richard J. Bende ORCID, Febe van Maldegem ORCID, Carel J. M. van Noesel
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.