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Oxford University Press (OUP), Bioinformatics, 13(24), p. i139-i146

DOI: 10.1093/bioinformatics/btn151

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Nucleosome positioning from tiling microarray data

Journal article published in 2008 by Moran Yassour ORCID, Tommy Kaplan, Ariel Jaimovich, Nir Friedman
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: The packaging of DNA around nucleosomes in eukaryotic cells plays a crucial role in regulation of gene expression, and other DNA-related processes. To better understand the regulatory role of nucleosomes, it is important to pinpoint their position in a high (5–10 bp) resolution. Toward this end, several recent works used dense tiling arrays to map nucleosomes in a high-throughput manner. These data were then parsed and hand-curated, and the positions of nucleosomes were assessed.