Although the ongoing information explosion within medicine is indisputably beneficial, it is difficult to stay abreast of the large volume of new information being published in the peer-reviewed and grey literature. Practical strategies to organize the swelling tide of medical literature are essential for providers to recognize and incorporate new information into their practice. One strategy for managing new information is the traditional annual review, in which selected, appraised articles are presented for general consumption. Here, we present five notable articles for general internal medicine published from 1 Sept. 2010 to 31 Aug. 2011, with focused summaries of their key findings and supporting clinical vignettes to highlight their significance.