A general method that uses potassium organotrifluoroborates in the Suzuki–Miyaura cross-coupling reaction with ring-brominated porphyrins has been investigated. The reaction conditions tolerate various functional groups and are applicable to the meso- and β-position as well as to aryl- and alkyl-substituted porphyrins. Depending on the nature of the potassium organotrifluoroborate, the coupling products can be obtained in yields of up to 75%. ; PUBLISHED ; Science Foundation Ireland Research Professorship grant (SFI/04/RP1/B482)