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Wiley, Neuromodulation: Technology at the Neural Interface, 5(18), p. 349-354, 2015

DOI: 10.1111/ner.12297

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Tremor Reduction by Deep Brain Stimulation Is Associated With Gamma Power Suppression in Parkinson's Disease.

Journal article published in 2015 by Martijn Beudel, Simon Little ORCID, Alek Pogosyan, Keyoumars Ashkan, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Marwan Hariz, Marko Bogdanovic, Binith Cheeran, Al Green, Tipu Aziz, Wesley Thevathasan, Peter Brown ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Rest tremor is a cardinal symptom of Parkinson's disease (PD), and is readily suppressed by deep brain stimulation (DBS) of the subthalamic nucleus (STN). The therapeutic effect of the latter on bradykinesia and rigidity has been associated with the suppression of exaggerated beta (13-30 Hz) band synchronization in the vicinity of the stimulating electrode, but there is no correlation between beta suppression and tremor amplitude. In the present study, we investigate whether tremor suppression is related to suppression of activities at other frequencies.