Published in
Wiley, British Journal of Pharmacology, 3(127), p. 747-755, 1999
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Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats: a role for increased nitric oxide production
Journal article published in 1999 by
Tomasz Wollny,
Giovanni de Gaetano 
,
Luca Aiello,
Donata Di Tommaso,
Vincenzo Bellavia,
Domenico Rotilio,
Maria Benedetta Donati ,
Licia Iacoviello
,
Luca Aiello,
Donata Di Tommaso,
Vincenzo Bellavia,
Domenico Rotilio,
Maria Benedetta Donati ,
Licia Iacoviello
This paper is made freely available by the publisher.
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Abstract
The effects of ethyl alcohol and wine (red and white) on haemostatic parameters and experimental thrombosis were studied in rats; NO was evaluated as a possible mediator of these effects.We found that red wine (12% alcohol) supplementation (8.4±0.4 ml d−1 in drinking water, for 10 days) induced a marked prolongation of ‘template' bleeding time (BT) (258±13 vs 132±13 s in controls; P