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Nature Research, Scientific Reports, 1(5), 2015

DOI: 10.1038/srep08631

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Number of sons contributes to ageing-associated inflammation

Journal article published in 2015 by Saara Marttila, Tapio Nevalainen ORCID, Laura Kananen, Juulia Jylh, Juulia Jylhävä, Marja Jylhä, Antti Hervonen, Jorma Ilonen, Mikko Hurme ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractThe rate of inflammation increases in elderly individuals, a phenomenon called inflammaging and is associated with degenerative diseases. However, the causes of inflammaging and the origin of the associated inflammatory mediators have remained enigmatic. We show herein that there is a positive correlation between the number of sons born and C-reactive protein concentrations in 90-year-old women. This association is influenced by HLA genetics known to regulate the immune response against HY antigens.