<i>Objectives:</i> This study assessed the <i>BRCA1</i> gene expression in breast cancer in Kuwait, and compared it with other known prognostic factors for the disease. <i>Materials and Methods:</i> Forty-eight random samples of archival paraffin-embedded breast cancer tissues were studied for <i>BRCA1</i> gene expression. Immunohistochemical method utilizing antibodies against different epitopes on the BRCA1 protein was used to study BRCA1 protein expression. In addition, for 29 patients, reverse transcription-polymerase chain reaction was used to detect <i>BRCA1</i> mRNA expression. <i>BRCA1</i> expression was correlated with age, histological type and grade of breast cancer, estrogen and progesterone receptor status, and C-erbB-2 expression. <i>Results:</i> No demonstrable <i>BRCA1</i> mRNA and protein expression was found in 79 and 83% of the breast cancer tissues, respectively. A positive relationship was demonstrated between lack of <i>BRCA1</i> (mRNA and protein) expression and high histological grade, negative estrogen and progesterone receptor status, and overexpression of C-erbB-2 in the breast cancer tissues. <i>Conclusions:</i> The study demonstrated lack of <i>BRCA1</i> gene expression (mRNA and protein) in the majority of breast cancers in Kuwait and confirmed the inverse relationship between <i>BRCA1</i> expression and parameters that determine poor prognosis in breast cancer.