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Karger Publishers, Dementia and Geriatric Cognitive Disorders, 6(10), p. 437-441, 1999

DOI: 10.1159/000017186

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Apolipoprotein E ε4 Is Associated with Neuronal Loss in the Substantia nigra in Alzheimer’s Disease

Journal article published in 1999 by Richard Camicioli ORCID, Jeffrey Kaye, Haydeh Payami, Melvyn J. Ball, Geoffrey Murdoch
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Apolipoprotein E ε4 (ApoE ε4) is associated with an earlier age at onset of Alzheimer’s (AD) and possibly Parkinson’s disease, suggesting a general role for ApoE ε4 in neuronal plasticity. Among 31 prospectively assessed subjects with pathologically confirmed AD (without Lewy bodies), ε4+ subjects had a longer duration of disease (by 2.8 years, p = 0.04). Only cell loss in the substantia nigra (p = 0.002) was associated with ε4. Neither neurofibrillary tangles nor plaque counts were associated with ε4. Cell counts of pigmented neurons in single midbrain sections in ε4+ specimens were 72% of those in ε4– substantia nigra (p = 0.04). These findings confirm that cell loss in the substantia nigra is associated with ε4 in AD.