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American Society of Hematology, Blood, 12(121), p. 2336-2339, 2013

DOI: 10.1182/blood-2012-09-455089

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VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease

Journal article published in 2013 by Alberto Tosetto, Zdena Vorlova, Jeroen Eikenboom, Federici Ab, Augusto B. Federici, Dirven Rj, Reinhard Schneppenheim, Francesco Rodeghiero, Dominique Meyer, Edith Fressinaud, Claudine Mazurier, Jørgen Ingerslev, Giancarlo Castaman, Ian Peake, Jenny Goudemand and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points VWFpp/VWF:Ag and FVIII:C/VWF:Ag ratios define the pathophysiological mechanisms that play a role in VWD and various VWF mutations. A high VWFpp/VWF:Ag ratio indicates increased clearance of VWF and a high FVIII:C/VWF:Ag ratio decreased synthesis of VWF.