Published in
American Physiological Society, Physiology, 4(21), p. 269-280, 2006
DOI: 10.1152/physiol.00004.2006
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Modulation of Vascular Smooth Muscle Signaling by Reactive Oxygen Species
Journal article published in 2006 by
Alicia N. Lyle,
Kathy K. Griendling
This paper is made freely available by the publisher.
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Abstract
Modulation of signaling in vascular cells by reactive oxygen species (ROS) affects many aspects of cellular function, including growth, migration, and contraction. NADPH oxidases, important sources of ROS, regulate many growth-specific and migration-related signaling pathways. Identifying the precise intracellular targets of ROS enhances understanding of their role in cardiovascular physiology and pathophysiology.