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National Academy of Sciences, Proceedings of the National Academy of Sciences, 34(106), p. 14265-14270, 2009

DOI: 10.1073/pnas.0900162106

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Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription

Journal article published in 2009 by Arounie Tavenet, Audrey Suleau, Géraldine Dubreuil ORCID, Roberto Ferrari, Cécile Ducrot, Magali Michaut ORCID, Jean-Christophe Aude, Aude Jc, Giorgio Dieci, Olivier Lefebvre, Christine Conesa, Joël Acker
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.