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Canadian Science Publishing, Canadian Journal of Physiology and Pharmacology, 2(70), p. 306-307

DOI: 10.1139/y92-038

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Glibenclamide depresses the slowly inactivating outward current (I<sub>D</sub>) in hippocampal neurons

Journal article published in 1992 by Valérie Crépel ORCID, Kresimir Krnjević, Yehezkel Ben-Ari, Y. Benari
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

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Data provided by SHERPA/RoMEO

Abstract

Sulphonylurea drugs, such as glibenclamide and tolbutamide, are widely used as selective blockers of adenosine triphosphate-sensitive K channels. In experiments on hippocampal slices (from Wistar rats) glibenclamide (and possibly gliquidone and tolbutamide) significantly reduced the highly voltage-dependent, 4-aminopyridine-sensitive D-type outward current of CA3 neurons. Judging by these observations, the sulphonylureas may not be as selective as generally believed.Key words: glibenclamide, gliquidone, tolbutamide, K currents, rat hippocampal slices.