Dissemin is shutting down on January 1st, 2025

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Oxford University Press, Nucleic Acids Research, 21(40), p. 10689-10700, 2012

DOI: 10.1093/nar/gks857

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The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila

Journal article published in 2012 by Dmitriy Gurskiy, Anastasija Orlova, Nadezhda Vorobyeva ORCID, Elena Nabirochkina, Alexey Krasnov, Yulii Shidlovskii, Sofia Georgieva, Daria Kopytova
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

SAGA/TFTC is a histone acetyltransferase complex that has a second enzymatic activity because of the presence of a deubiquitination module (DUBm). Drosophila DUBm consists of Sgf11, ENY2 and Nonstop proteins. We show that Sgf11 has other DUBm-independent functions. It associates with Cbp80 component of the cap-binding complex and is thereby recruited onto growing messenger ribonucleic acid (mRNA); it also interacts with the AMEX mRNA export complex and is essential for hsp70 mRNA export, as well as for general mRNA export from the nucleus. Thus, Sgf11 functions as a component of both SAGA DUBm and the mRNA biogenesis machinery.