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Nature Research, Scientific Reports, 1(2), 2012

DOI: 10.1038/srep00910

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Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate

Journal article published in 2012 by Marie-Hélène Canron, Martine Perret, Anne Vital, Erwan Bézard ORCID, Benjamin Dehay
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Since age-dependent deposition of Aβ-amyloid has been reported in the Microcebus murinus, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of Microcebus murinus aged from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs spontaneously in mouse lemur primates. Microcebus murinus may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases.