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American Association for the Advancement of Science, Science, 5809(315), p. 207-212, 2007

DOI: 10.1126/science.1132894

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Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis

Journal article published in 2007 by Yves Van de Peer, Jane M. Carlton, Robert P. Hirt, U. Cecilia M. Alsmark, Joana C. Silva, Arthur L. Delcher, Michael Schatz, Qi Zhao, Jennifer R. Wortman ORCID, Shelby L. Bidwell, U. Cecilia M. Alsmark, Sébastien Besteiro, U. C. M. Alsmark, Thomas Sicheritz-Ponten, Christophe J. Noel and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the similar to 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.