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American Society for Microbiology, Clinical and Vaccine Immunology, 1(9), p. 194-197, 2002

DOI: 10.1128/cdli.9.1.194-197.2002

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Influence of Host Factors on Immunoglobulin G Concentration in Oral Fluid Specimens

Journal article published in 2002 by Timothy C. Granade, J. Richard George, Susan K. Phillips, Wendy Kitson-Piggott, Perry Gomez, Bisram Mahabir, Herbert Oleander, J. Richard George, James Baggs ORCID, Bharat Parekh
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The influence of host factors (tobacco use, dentition, bleeding gums, oral rinsing, nasal medications, and time since the last meal) on immunoglobulin G (IgG) concentration in oral fluids (OF) was determined by univariate and multivariate analysis. Significant differences in IgG concentration were found to be associated with human immunodeficiency virus (HIV) status (HIV antibody positive, +16.60 microg/ml, P = 0.0001), sex (female, +1.23 microg/ml, P = 0.004), dentition (+2.83 microg/ml, edentulous versus dentulous, P = 0.0001), bleeding gums (+6.35 microg/ml, P = 0.0001), and time since the last meal (+3.55 microg/ml, >6 h, P = 0.0001). These factors could impact diagnostic methods that rely on the immunoglobulin concentration in OF specimens.