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Cell Press, Cell Metabolism, 3(13), p. 241-247, 2011

DOI: 10.1016/j.cmet.2011.02.004

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Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus

Journal article published in 2011 by Guido T. Bommer ORCID, Ormond A. MacDougald
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved in cholesterol biosynthesis, and microRNA-33a, which has recently been shown to reduce expression of proteins involved in export of cholesterol and β-oxidation of fatty acids, thus adding an unexpected layer of complexity and fine-tuning to regulation of lipid homeostasis.