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Elsevier, Current Opinion in Immunology, 3(25), p. 321-328

DOI: 10.1016/j.coi.2013.05.010

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Transcriptional regulation of effector and memory CD8+ T cell fates

Journal article published in 2013 by James Ed D. Thaventhiran, Douglas T. Fearon, Luca Gattinoni ORCID
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This paper is available in a repository.

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Abstract

Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream transcriptional programs ultimately guiding a CD8(+) T cell to undertake either an effector or a memory cell fate. Here, we discuss our current understanding of the signaling pathways and transcriptional networks that regulate effector and memory commitment in CD8(+) T lymphocytes.