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American Society for Clinical Investigation, Journal of Clinical Investigation, 6(121), p. 2118-2125, 2011

DOI: 10.1172/jci45680

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Dynamics of insulin secretion and the clinical implications for obesity and diabetes

Journal article published in 2011 by Susumu Seino, Tadao Shibasaki, Kohtaro Minami ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism. Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and discusses their clinical relevance.