The physical state of interstellar gas and dust is dependent on the processes which heat and cool this medium. To probe heating and cooling of the ISM over a large range of infrared surface brightness, on sub-kiloparsec scales, we employ line maps of [C \ii] 158 $μ$m, [O \one] 63 $μ$m, and [N \ii] 122 $μ$m in NGC 1097 and NGC 4559, obtained with the PACS spectrometer onboard {\it Herschel}. We matched new observations to existing Spitzer-IRS data that trace the total emission of polycyclic aromatic hydrocarbons (PAHs). We confirm at small scales in these galaxies that the canonical measure of photoelectric heating efficiency, ([C \ii] + [O \one])/TIR, decreases as the far-infrared color, $ν f_ν$(70 $μ$m)/$ν f_ν$(100 $μ$m), increases. In contrast, the ratio of far-infrared (far-IR) cooling to total PAH emission, ([C \ii] + [O \one])/PAH, is a near constant $∼$6% over a wide range of far-infrared color, 0.5 \textless\ $ν f_ν$(70 $μ$m)/$ν f_ν$(100 $μ$m) $\lesssim$ 0.95. In the warmest regions, where $ν f_ν$(70 $μ$m)/$ν f_ν$(100 $μ$m) $\gtrsim$ 0.95, the ratio ([C \ii] + [O \one])/PAH drops rapidly to 4%. We derived representative values of the local UV radiation density, $G_0$, and the gas density, $n_H$, by comparing our observations to models of photodissociation regions. The ratio $G_0/n_H$, derived from fine-structure lines, is found to correlate with the mean dust-weighted starlight intensity, $$ derived from models of the IR SED. Emission from regions that exhibit a line deficit is characterized by an intense radiation field, indicating that small grains are susceptible to ionization effects. We note that there is a shift in the 7.7 / 11.3 $μ$m PAH ratio in regions that exhibit a deficit in ([C \ii] + [O \one])/PAH, suggesting that small grains are ionized in these environments.