From Blight to Powdery Mildew Pathogenic effects of microbes on plants have widespread consequences. Witness, for example, the cultural upheavals driven by potato blight in the 1800s. A variety of microbial pathogens continue to afflict crop plants today, driving both loss of yield and incurring the increased costs of control mechanisms. Now, four reports analyze microbial genomes in order to understand better how plant pathogens function (see the Perspective by Dodds ). Raffaele et al. (p. 1540 ) describe how the genome of the potato blight pathogen accommodates transfer to different hosts. Spanu et al. (p. 1543 ) analyze what it takes to be an obligate biotroph in barley powdery mildew, and Baxter et al. (p. 1549 ) ask a similar question for a natural pathogen of Arabidopsis . Schirawski et al. (p. 1546 ) compared genomes of maize pathogens to identify virulence determinants. Better knowledge of what in a genome makes a pathogen efficient and deadly is likely to be useful for improving agricultural crop management and breeding.