Published in
Wiley, British Journal of Haematology, 2(171), p. 273-276, 2015
DOI: 10.1111/bjh.13553
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Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania
,
Josephine Mgaya,
Emmanuel Balandya,
Khadija Msami,
Deogratias Soka,
Sharon E. Cox,
Albert N. Komba,
Stella Rwezaula,
Elineema Meda,
David Muturi,
Jesse Kitundu,
Gregory Fegan,
Fenella J. Kirkham,
Charles R. Newton ,
Robert W. Snow
and other authors.
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Abstract
Bacteraemia is a leading cause of morbidity in sickle cell anaemia (SCA), but information from studies in Africa is limited. We evaluated 890 admissions from 648 SCA patients at a tertiary hospital in Tanzania. Bacteraemia was present in 43 admissions (4·8%); isolates included Staphylococcus aureus (12/43; 28%), non-Typhi Salmonella (9/43; 21%), Streptococcus pneumoniae (3/43; 7%) and Salmonella Typhi (2/43; 5%). Compared to SCA patients without bacteraemia, SCA patients with bacteraemia had significantly lower haemoglobin [71 g/l vs. 62 g/l, odds ratio 0·72 (95% confidence interval 0·56-0·91), P