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Wiley, Acta Psychiatrica Scandinavica, 6(131), p. 408-416, 2014

DOI: 10.1111/acps.12381

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Drug dose as mediator of treatment effect in antidepressant drug trials: the case of fluoxetine

Journal article published in 2014 by M. Purgato, C. Gastaldon ORCID, D. Papola ORCID, L. R. Magni ORCID, G. Rossi, C. Barbui
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

This study aimed at investigating whether dose is a mediator of treatment effect in fluoxetine-randomized trials. Specifically, we investigated whether dose was higher in trials in which the aim was to demonstrate fluoxetine efficacy in comparison with older antidepressants and lower in trials in which the aim was to demonstrate a new drug's efficacy against fluoxetine.