Medieval Vienna was situated at the main arm of the swiftly flowing alpine Danube. From the fourteenth century onwards, the river gradually moved away from the city. This marked the beginning of 500 years of human intervention to prevent further displacement of the river and to preserve the waterway as a vital supply line. Archival research and the GIS-based reconstruction of the past riverscape allow a new view about the co-evolution of the city and the river. Following major channel changes in 1565/1566, repeated attempts to force the main arm into the old river bed were undertaken. By the early seventeenth century, the Viennese had accepted the new situation. Resources were now spent on maintaining the waterway to the city via the remaining Wiener arm. After the second Ottoman siege in 1683, improving the navigability of the Wiener arm, in conjunction with major expansions of the fortifications, became the main issue. Between 1775 and 1792, the first systematic, effective flood protection measures were established. These substantially influenced fluvial dynamics and enabled urban development in parts of the former floodplain. The all-embracing transformation of the dynamic riverscape into stabilised areas enabling urban growth and secure waterways was not achieved until 1875. With this successful “re-invention” of the Viennese Danube, an irreversible path was struck in the common life of the city and the river, a path which is still decisive for the interaction of Vienna with that great European river.