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Frontiers Media, Frontiers in Neuroscience, (9), 2015

DOI: 10.3389/fnins.2015.00017

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A unique array of neuroprotective effects of pyruvate in neuropathology

Journal article published in 2015 by Yuri Zilberter, Olena Gubkina, Anton I. Ivanov ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The three common signature characteristics of many neurological diseases are brain hypometabolism, oxidative stress, and neuroinflammation (Melo et al., 2011; Cai et al., 2012; Heneka et al., 2014). In order to be efficient, successful treatment should targetall three pathologies simultaneously. Pyruvate seems to be an ideal candidate for such a treatment because of its unique combination of neuroprotective effects (Figure 1). In this opinion paper, we attempt to review and summarize recent information concerningthese effects and their significance for neuroprotection.