Elsevier, Journal of Allergy and Clinical Immunology, 4(135), p. 998-1007.e6, 2015
DOI: 10.1016/j.jaci.2014.08.030
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Immunoglobulin class-switch recombination defects (CSR-D) are rare primary immunodeficiencies characterized by impaired production of switched immunoglobulin isotypes and normal or elevated IgM levels. They are caused by impaired T:B cooperation or intrinsic B cell defects. However, many immunoglobulin CSR-Ds are still undefined at the molecular level.